Intrommune Therapeutics Featured On Unicorn Hunters

Safe and Effective Food Allergy Therapies

Intrommune Therapeutics is dedicated to developing safe and effective options for food allergy sufferers so they and their loved ones can live their lives without fear.

About Us

With over 32 million Americans suffering from food allergies, Intrommune is focused on developing a safe, disease-modifying treatment with long-term efficacy through our oral mucosal immunotherapy (OMIT) platform that can help provide a much-needed solution.

family selfie for birthday
teacher and students eating lunch
dad making peanut butter sandwich
girl looking at cookies
family sharing food at table
mom and daughter brushing teeth

Our Science

Our novel drug delivery platform provides a simple solution for food allergies by embedding therapeutic agents in a fully functional toothpaste that can be conveniently administered as daily treatment at the same time patients brush their teeth.

Intrommune toothpaste delivers allergen protein
Toothpaste slurry coats the mouth so more allergen protein can bind with cells on the surface of the oral mucosal epithelium. The opposing charges of the protein and surface cells attracts them to each other to form a strong bond.
Langerhans Cells process and display allergen proteins
Oral Langerhans cells capture allergen protein as it diffuses into the oral mucosa, displaying key identifiers on their surface before travelling to regional lymph nodes.  
Langerhan cells trigger the re-education of the immune system
Once in the regional lymph nodes Langerhans cells activate naive T cells causing them to differentiate into either T regulatory (Treg) cells or T helper type 1 (Th1) cells.
Differentiated T Cells decrease the allergic response
Treg and Th cells travel through lymph vessels and distribute themselves throughout the mucosa of the aerodigestive tract where they decrease the allergic immune response the next time there is exposure to the specific allergen protein. 
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